Detection of a Cephalosporin C Acetyl Esterase in the Carbamate Cephalosporin Antibiotic-Producing Culture, Streptomyces clavuligerus
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Biosynthesis of cephalosporin C.
The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cy...
متن کاملPurification and characterization of a cephalosporin esterase from Rhodosporidium toruloides.
A novel cephalosporin esterase (EC 3.1.1.41) from Rhodosporidium toruloides was purified to gel electrophoretic homogeneity. The enzyme is a glycoprotein with a molecular mass of 80 kDa. Upon deglycosylation, several forms of the enzyme were observed with a molecular mass range between 60 and 66 kDa. The isoelectric point of the enzyme is approximately 5.6, with the pH optimum for activity occu...
متن کاملThe X - Ray Analysis of Cephalosporin C
Bulow, C. & Seidel, F. (1924). Liebigs Ann. 439, 48. Cavallini, D., Frontali, N. & Toschi, G. (1949). Nature, Lond., 163, 568. De Ropp, R. S., Van Meter, J. C., De Renzo, E. C., McKerns, K. W., Pidacks, C., Bell, P. H., Ullman, E. F., Safir, S. R., Fanshawe, W. J. & Davis, S. B. (1958). J. Amer. chem. Soc. 80, 1004. Ellington, E. V., Hassall, C. H. & Plimmer, J. R. (1958). Chem. & Ind. p. 329. ...
متن کاملThe synergistic action of cephalosporin C and benzylpenicillin against a penicillinase-producing strain of Staphylococcus aureus.
Cephalosporin C, a hydrophilic, penicillin-like antibiotic which is insensitive to penicillinase, is much less active than benzylpenicillin against the Oxford strain of Staphylococcus aureus but much more active than benzylpenicillin against a penicillinase-producing strain of S. aureus (D3R). When used together, cephalosporin C and benzylpenicillin act synergistically against S . aureus strain...
متن کاملCefuroxime, a new cephalosporin antibiotic: activity in vitro.
Cefuroxime is a new broad-spectrum cephalosporin antibiotic with increased stability to beta-lactamases. This stability, although no absolute in all cases, has the effect of widening the antibacterial spectrum of the compound so that many organisms resistant to the established cephalosporins are susceptible to cefuroxime. It is active against gram-positive organisms, including penicillinase-pro...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1972
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.1.3.237